Territorial development –urban and rural– needs to take into account intelligently the process of growth of the different economic and social sectors, a process in which development banking plays an important role in promoting and financing it. From the promotion of cities of knowledge where innovation for activities with high added value based on state-of-the-art technology; the sustainable sectorial and productive development, functional to the projection of the city and the country and to the narrowing the rural-urban gap; as well as the continued reinvention of development financial institutions to be able to address the challenges posed by the structural change of our economies and the optimization of the impact of their financial action; the variables knowledge, innovation and technology permeate the diverse aspects on which today’s development banking gravitate as a modern and vital instrument of public policy in the Latin American and the Caribbean process of economic change.